REACH Annex XVII adds restriction requirements for DMAC and NEP

On June 3, 2025, the Official Journal of the European Union (OJ) published the Commission Regulation (EU) 2025/1090 amending Annex XVII to Regulation (EC) No 1907/2006, adding entry 80 and entry 81 to Annex XVII of REACH, officially restricting the use of N,N-dimethylacetamide (DMAC) and 1-ethylpyrrolidin-2-one (NEP).This Regulation shall enter into force on the twentieth day following that of its publication in the Official Journal of the European Union.
In Annex XVII to Regulation (EC) No 1907/2006, the following entries are added:

Tips from CTT：
N,N-dimethylacetamide (DMAC) and 1-ethylpyrrolidin-2-one (NEP) are dipolar aprotic solvents. DMAC and NEP are used in industrial settings and by professionals as solvents in the formulation of mixtures, for example in agrochemicals, pharmaceuticals and fine chemicals. Due to their developmental and reproductive toxicity, these two types of substances are restricted for use under Annex XVII of REACH. CTT reminds relevant enterprises to prepare in advance, strengthen raw material and factory inspection control, and ensure that products meet regulatory requirements.

Original link：https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX%3A32025R1090&qid=1749000476518